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Keywords:
Abdomen, Oncology, Paediatric, Ultrasound, Ultrasound-Colour Doppler, Ultrasound-Power Doppler, Diagnostic procedure, Staging, Screening, Cancer, Congenital, Pathology
Authors:
I. Begun, O. Krasko; Minsk/BY
DOI:
10.1594/ecr2014/C-1997
Aims and objectives
Despite on the initiation embryonic malignancies of fetus in utero and the widespread availability of ultrasound (US) for pregnant in most cases embryonic malignancies are diagnosing in infants postnatally when there are a specific clinical symptoms and significant tumor volume.
Median age of the actual primary imaging embryonic malignancies such as neuroblastoma,
nephroblastoma and hepatoblastoma in children under one year according to own data is 6 months and the median tumor volume - 176 (39,5–355) cm³.
Currently,
by results of mandatory prenatal ultrasound is possible detect relatively small proportion of embryonic malignancies,
that subsequently were diagnosed in infants [1-3].
This may indicate that there are certain diagnostic prenatal ultrasound reserves.
Also,
it does not contradict to hypothesis of prenatal growth suppression deterministic malignant embryonal tumors [4].
Is why development and of postnatal screening programs using ultrasound is necessary.
Implementation of effective screening in children under one year due to objective reasons are constrained,
and not the last role is played here by the economic factor.
Has not been studied the dynamics of growth of embryonic malignancies during the prenatal and early postnatal periods.
Known theories and hypotheses embryonic tumors,
implying initiation of the tumor in fetus (Cohnheim,
1867; Knudson,
1972) and the continuity of its growth (Collins,
1955) [5-7],
at the same time do not give of detailed presentation about the dynamics of the tumor process in association with an age of child.
Despite the increasing number of publications on issues of modeling the of tumors growth,
works,
which proposed the mathematical modeling of the embryonic tumors using data obtained in the clinic,
we have not found.
The study of patterns of tumor development in the perinatal period,
the construction of the trend models using of postnatal clinical data can help assess the dynamics of the growth of embryonic tumors,
terms of metastasis and outline ways to better identify of substrate of the disease in infants.
The purpose of research - modeling of the dynamics of growth of embryonic tumors (nephroblastoma,
retroperitoneal neuroblastoma and hepatoblastoma) in infants for determine the optimal age of effective diagnosis of malignant tumors in the early stages.