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Keywords:
Abdomen, Oncology, Paediatric, Ultrasound, Ultrasound-Colour Doppler, Ultrasound-Power Doppler, Diagnostic procedure, Staging, Screening, Cancer, Congenital, Pathology
Authors:
I. Begun, O. Krasko; Minsk/BY
DOI:
10.1594/ecr2014/C-1997
Methods and materials
Following an initial ultrasound diagnosis of malignant neoplasms of 109 children of both sexes aged 1–366 days were studied by volumetric and kinetic characteristics tumors.
All patients were with confirmed diagnoses of the nephroblastoma (n=31),
retroperitoneal neuroblastoma & neuroblastoma adrenal (n=58) and hepatoblastoma (n=20) morphologically (see Fig.
1-4).
Tumor volume (V,
cm³) was determined by ultrasound,
counting it's by formula V = 0.523aхbхc,
where a – length,
b – width,
c – tumor thickness (in cm) or in program VOCALTM (Virtual Organ Computer Aided anaLysis) - Fig.
5.
We use Gompertz equation of the following form (Fig.
6):
Fig. 6: Gompertz equation
References: Gompertz, B., On the nature of the function expressive of the law of human mortality and on a new model of determining life contingencies, Philos. Trans. R. Soc. (Lond.), 115 (1825) pp. 513-585.
(1),
where V0 is the tumor size at time t0,
V(t) is the tumor volume at time t,
and А and λ are constants.
Growth rate is (Fig.
7).
Fig. 7: Growth rate equation
(2).
Thus,
the time point of maximum growth rate can be calculated as follows (Fig.
8):
Fig. 8: Equation of time point with the maximum growth rate
(3).
The statistical package R was used to perform statistical computing [8].