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Keywords:
Breast, Oncology, MR, Diagnostic procedure, Cancer
Authors:
M. Nadrljanski, R. Maksimovic, V. Plesinac-Karapandzic, M. Nikitovic, Z. C. Milosevich; Belgrade/RS
DOI:
10.1594/ecr2015/B-0016
Results
The average tumor size initially in R and NR (as shown in Table 1),
was not significantly different: 2.99+/-0.57 cm vs.
3.33+/-0.49 cm; p>0.05
The difference in ADC between R and NR,
was considered highly statistically significant initially: 1.004+/-0.009 mm2/s x 10-3 vs.
0.840+/-0.134 mm2/s x 10-3; p=0.0001
RESPONDERS:
After the 2nd cycle of NACT,
ADC value increased significantly in R: 1.004+/-0.009 vs.
1.284+/-0.005; p=0.05 and the change was +27.89% (Fig.
1,
2).
Although the change in tumor size according to RECIST in R was considered significant after the 2nd cycle (2.99+/-0.57 cm vs.
2.59+/-0.53 cm; p<0.0001),
the assigned response category according to RECIST was SD (-15.44%) (Fig.
1,
2).
In R,
only moderate correlation between ADC and RECIST was noted after the 2nd cycle of NACT (r=0.49).
NONRESPONDERS:
After the 2nd cycle of NACT,
ADC value was not significantly different in NR: 0.840 +/- 0.147 mm2/s x 10-3 vs.
0.872 +/- 0.134 mm2/s x 10-3; p>0.05 and the change was 3.81% (Fig.
3).
Although the change in tumor size according to RECIST in R was considered significant after the 2nd cycle (3.33 +/- 0.49 cm vs.
3.18 +/- 0.49 cm; p<0.001),
the assigned response category according to RECIST was SD (-4.50%) (Fig.
3).
The difference in ADC value between R and NR after the 2nd cycle of NACT was considered highly statistically significant: 1.284 +/- 0.005 mm2/s x 10-3 vs.
0.872 +/- 0.134 mm2/s x 10-3; p<0.0001.