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Breast, Oncology, Mammography, MR, Chemotherapy, Cancer, Neoplasia
S. Ravaioli1, R. Sghedoni1, A. Nitrosi1, V. Iotti1, C. Coriani1, R. Vacondio1, C. A. Mori1, V. Ginocchi2, P. Pattacini1; 1Reggio Emilia/IT, 2Guastalla/IT
Methods and materials
43 consenting women with in situ,
lobular or ductal carcinoma and with indication of neoadjuvant chemotherapy (NAC) were enrolled into this prospective study between October 2012 and October 2014.
The patients underwent CESM and CE-MRI before,
after the first NAC cycle and after the end of NAC.
29 patients completed the therapy up to October 2014.
Response to therapy was evaluated for each patient using the variation of the largest dimension of malignancies measured on CE-MRI and CESM image sets.
A CESM examination consisted in a pair of low and high energy exposures for each mammographic view,
combined to visualize lesions with contrast up-take.
CESM and CE-MRI size measurements were compared through correlation (Pearson) and agreement (Paired t-test).
Clinical outcomes were also compared: patients were considered as responding to therapy when size reduction after NAC was larger than 30%.