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Keywords:
Oncology, Neuroradiology brain, Contrast agents, CT, Computer Applications-Detection, diagnosis, Contrast agent-intravenous, Radiation therapy / Oncology, Cancer
Authors:
T. S. Koh, C. H. Thng, P. T. H. Teo, D. Cheong, K. Lim, J. B. K. Khoo, T. Lim; Singapore/SG
DOI:
10.1594/ecr2015/C-0038
Results
Before and immediately after radiotherapy (Fig.
1),
classification analysis revealed that the tumour voxels are largely associated with a distinct cluster,
which exhibited a strong wash-in and plateau enhancement pattern,
different from the surrounding tissues.
Six weeks after radiotherapy (Fig.
2),
tumour voxels are classified into another distinct cluster with a gentler wash-in and progressively increasing pattern.
Sixteen weeks after radiotherapy (Fig.
3),
voxel locations where the tumour previously resided are no longer associated with a separate cluster from the surrounding tissues,
indicative of tissue normalization.
Fig. 1: Fig. 1. Automatic classification of voxel enhancement patterns in DCE CT datasets of a patient before and immediately after whole brain radiotherapy. Each colored region in the brain maps corresponds to the enhancement pattern of the same color in the respective mean signal plots.
Fig. 2: Fig. 2. Automatic classification of voxel enhancement patterns in DCE CT datasets of a patient at 6 weeks after whole brain radiotherapy.
Fig. 3: Fig. 3. Automatic classification of voxel enhancement patterns in DCE CT datasets of a patient at 16 weeks after whole brain radiotherapy.