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Keywords:
Nuclear medicine, Professional issues, Computer applications, PET-CT, Complications, Outcomes analysis, Biological effects
Authors:
Y. Kono, K. Utsunomiya, K. Nakano, N. Tanigawa; Osaka/JP
DOI:
10.1594/ecr2015/C-0441
Aims and objectives
Maximum standardized uptake value (SUVmax) is a commonly used as a semiquantitative parameter in PET/CT studies valuable for diagnosis of various diseases and therapy response.
However,
It is reported that SUVmax is modified by various factors,
differs from the true value,
then it makes undervalue or overvalue patient conditions.
We have experienced that SUVmax is occasionally not useful to diagnose and compare with other patients in clinical.
It was known that patient’s physique make it be difficult to get true SUVmax,
and it is reported to the over weight especially that SUVmax becomes an excessive evaluation in the patient.
Using lean body mass normalized SUVmax (SUL) is weight-independent indice for FDG uptake,
and SUVmax appears to be more appropriate for quantifying FDG uptake to avoid overestimation of glucose utilization in obese patients1). Also SUL is used in the therapy evaluation in PERCIST1.0 advocated as therapy evaluation2).
Moreover,
a lot of methods of obtaining lean body mass (LBM) from the calculation are instituted,
and the calculating formula to which Morgan DJ et al.
modified the James method is adopted widely now3).
Whether using the predictive equation SUVmax (SULPE) could be clinical suitable or not is uncertain.
The purpose of the present study is that SUVmax obtained from the actual measurement value of the body fat scale (SULS) is defined as Golden standard,
and evaluate SULPE by comparing in physiological accumulation and to clarify the differences among body type in SUVmax