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Keywords:
Breast, Mammography, Screening, Statistics, Cancer, Epidemiology
Authors:
A. M. Rosso1, I. F. Petersson1, K. Lang2, S. Zackrisson2; 1Lund/SE, 2Malmö/SE
DOI:
10.1594/ecr2015/C-1124
Results
In order to obtain a simple classification scheme to predict which groups of women that would be recalled a C&RT is calculated.
The results are shown in Figure 1.
By using DBT,
98.5 % (92.1 %,
100.0 %) of screened women with BC would be recalled for further examinations.
In the case of DM 69.1 % (56.7 %,
79.8 %) of cancer cases would be detected.
The recall of healthy women is mainly affected by breast density for both methods.
The probability of a false-positive recall using DBT is expected to be 2.1 % (1.7 %,
2.6 %) and 4.8 % (4.1 %,
5.7 %),
for fatty (BI-RADS 1,
2) and dense (BI-RADS 3,
4) breasts,
respectively.
For DM it is 1.4 % (1.0 %,
1.8 %) and 3.5 % (2.8 %,
4.3 %).
Furthermore,
the influence of breast density and patient age on the probability of false-positive BC screening is analysed using a generalized lineal model,
results shown in Figures 2 and 3.
For both DBT and DM,
breast density is the most important factor.
Patient age does not affect the probability of a false-positive BC screening result in a significant way.
As breast density increases,
the probability of a false-positive BC screening result also increases.
In the screening population we observe around 19.8 % (n=1314),
37.8 % (n= 2512),
33.9 % (n=2252) and 8.5 % (n= 562) of women with BI-RADS density 1,
2,
3 and 4 respectively.
By using these parameters it is estimated that approximately 33 and 23 women would get a false-positive BC screening result per 1000 screened women for DBT and DM,
respectively.
We also calculated the expected amount of false-positive BC screening results for each breast density.
For fatty breasts with density 1 or 2,
3 and 9 women per 1000 screened women would have false-positive BC screening results with DBT compared to 2 and 7 with DM.
Our results may also indicate that the false-positive BC probability increases more for DBT than for DM for dense breasts.
In this case,
15 and 6 false-positive BC screenings per 1000 screened women are expected for women with breast density 3 and 4 respectively for DBT compared to 10 and 4 for DM.