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Keywords:
Cancer, Diagnostic procedure, Contrast agent-intravenous, Ultrasound, Elastography, Thyroid / Parathyroids, Head and neck
Authors:
H. Wu1, Q. Chen2, Q. Zhou2, Y. Liu3, J. Luo2, J. Chen2; 1Zunyi/CN, 2Chengdu/CN, 3Beijing/CN
DOI:
10.1594/ecr2015/C-1739
Methods and materials
Patients with confirmed TI-RADS Category 3/4 thyroid nodules by an experienced operater were evaluated by other 2 experienced operaters with shear wave elastography.
The potentially influencing factors of size,depth,localization and calcification were grouped and studied.
The SWE parameters(MEAN,
MIN,
MAX and SD) of nodules were measured through the first Q-Box covering the whole nodule and simultaneously,
the second Q-Box putting in the relatively normal thyroid parenchyma with the diameter of 3mm.Both of them were measured 3 times respectively and the EIs(elastographic indices) for average(MEANavg,
MINavg,
MAXavg and SDavg) of the nodules and for the differences between nodules and normal thyroid (MEANd,
MINd,
MAXd,
SDd) and ratios of nodules to normal thyroid (MEANr,
MINr,
MAXr,
SDr) were calculated and used to create receiver operator characteristic(ROC) curves.The Pearson correlation was used to assess the relationship between the EIs of benign/malignant nodules and the size/depth of the nodules respectively.
The independent sample t-test was used to compare the differences of the EIs of benign/malignant nodules in different groups of size/depth/location(α=0.05,P<0.05).
Sensitivity,
specificity,
accuracy,
positive predictive value (PPV),
and negative predictive value (NPV) were determined.
The reliability of quantitative measurements was assessed by intraclass correlation coefficients(ICC,<0.4 for poor reliability,0.4-0.75 for moderate reliability and >0.75 for good reliability).