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Type:
Educational Exhibit
Keywords:
Breast, Oncology, Mammography, Ultrasound, Elastography, Diagnostic procedure, Pathology, Cancer
Authors:
R. M. Sgarbura1, A. I. Ciurea2; 1Sibiu/RO, 2Cluj-Napoca/RO
DOI:
10.1594/ecr2015/C-2109
Background
ILC is the second most common histological type of breast cancer,
accounting for approximately 10%–15% of all invasive breast cancers [1].
Compared with the more common invasive ductal carcinoma (IDC),
ILC has different etiological,
clinical and biological features [2].
ILC is characterized by small,
round cells,
with a scant cytoplasm and lack of E-cadherin (cell adhesion molecule).
The classic form of ILC has a typical growth pattern,
with the cells infiltrating the stroma in a single file and surrounding benign breast tissues with a specific “bull’s-eye” pattern.
Due to E-cadherin loss,
in ILC can be little or no desmoplastic reaction,
with no secondary architectural distortion [1-6].
This makes it difficult to detect by palpation or mammography,
and ILC is often larger at presentation than IDC [2].
ILC comprises several variants: signet ring,
alveolar,
solid,
and pleomorphic types [1].