The inter-observer agreement was good (κ=0,71±0,15).
There were no statistically significant differences between biparametric and multiparametric MRI in the performance of MR in local staging.
Sensitivity of biparametric and multiparametric MRI for F-EPE was respectively 65,4% and 55,8% (p=0,32); specificity was 87,8% and 91,1% (p=0,47); positive predictive value (PPV) was 75,6% and 78,4% (p=0,76); negative predictive value (NPV) was 81,4% and 78,1% (p=0,55); accuracy was 79,6% and 78,2% (p=0,77).
The diagnostic parameters of F-EPE are summarized in Table 2 and Figure 1.
|
Focal extraprostatic extension (F-EPE)
|
|
Biparametric
|
Multiparametric
|
p
|
Sensitivity
|
65,4%
|
55,8%
|
0,32
|
Specificity
|
87,8%
|
91,1%
|
0,47
|
PPV
|
75,6%
|
78,4%
|
0,76
|
NPV
|
81,4%
|
78,1%
|
0,55
|
Accuracy
|
79,6%
|
78,2%
|
0,77
|
Tab.
2: diagnostic parameters of F-EPE in biparametric and multiparametric MRI
The same analysis was performed for NF-EPE (sensitivity 87,5% and 81,3%,
p=0,99; specificity 75% and 80,6%,
p=0,28; PPV 31,1% and 35,1%,
p=0,70; NPV 97,9% and 97,1%,
p=0,99; accuracy 75,4% and 79,6%,
p=0,34) and SV invasion (sensitivity 40% and 30%,
p=0,99; specificity 97% and 97,7%,
p=0,99; PPV 50% and 50%,
p=1; NPV 95,5% and 94,9%,
p=1; accuracy 93% and 93%,
p=1),
with no statistically differences between the two protocols.
The diagnostic parameters of NF-EPE and SV are summarized in Table 3-4 and Figure 2-3.
|
Nonfocal extraprostatic extension (NF-EPE)
|
|
Biparametric
|
Multiparametric
|
p
|
Sensitivity
|
87,5%
|
81,3%
|
0,99
|
Specificity
|
75,0%
|
80,6%
|
0,28
|
PPV
|
31,1%
|
35,1%
|
0,70
|
NPV
|
97,9%
|
97,1%
|
0,99
|
Accuracy
|
75,4%
|
79,6%
|
0,34
|
Tab.
3: diagnostic parameters of NF-EPE in biparametric and multiparametric MRI
|
Seminal vescicles invasion (SV)
|
|
Biparametric
|
Multiparametric
|
p
|
Sensitivity
|
40,0%
|
30,0%
|
0,99
|
Specificity
|
97,0%
|
97,7%
|
0,99
|
PPV
|
50,0%
|
50,0%
|
1
|
NPV
|
95,5%
|
94,9%
|
1
|
Accuracy
|
93,0%
|
93,0%
|
1
|
Tab.
4: diagnostic parameters of SV in biparametric and multiparametric MRI