Keywords:
Oncology, Genital / Reproductive system male, MR physics, MR-Diffusion/Perfusion, MR-Functional imaging, MR-Angiography, Contrast agent-other, Image compression, Cancer, Neoplasia
Authors:
Y. Zhang, C. Wei, M. J. Szewczyk-Bieda, S. Lang, G. Nabi; Dundee/UK
DOI:
10.1594/ecr2018/C-1200
Results
1.The cut-off value to differentiate benign and prostate cancer tissue were Kep (1.18 min-1; sensitivity: 55%,
specificity: 68%) and Ve(0.24 min-1; sensitivity: 62%,
specificity: 61%) in the Tofts&Kermode model(TK) (Fig.2),
Ktrans(0.145 min-1; sensitivity:67%,
specificity:57%) in extended Tofts model(ET) (Fig.3).
2.The quantitative parameters above cut-off value were analysed correlation with pathological results.
Quantitative parameter Ve_TK (Fig.4) and Ktrans_ET (Fig.6) had strong positive correlation with Gleason Score.
Medium value for Ve_TK with Gleason Score 6,
7 and >7 were 0.17 min-1,
0.32 min-1,
0.41 min-1 respectively and for Ktrans_ET were 0.12 min-1,
0.18 min-1,
0.31 min-1 respectively,
indicating that quantitative parameters could not only differentiate benign and malignant lesions ,
but also grade different kinds of prostate cancers.
3.The mean values of Ve_TK for cancer with Gleason Score 6,
7 and >7 were 0.209 min-1,
0.355 min-1,
0.563 min-1 respectively (Fig.5).
For Ktrans_ET were 0.162 min-1,
0.255 min-1,
0.352 min-1 (Fig.7).
Mean value also showed favourable correlation with cancer grade.