Keywords:
Pathology, Biopsy, MR-Spectroscopy, MR, Liver, Abdomen
Authors:
A. M. Lapadat, L. M. Florescu, S. Bondari, I. A. Gheonea; Craiova/RO
DOI:
10.1594/ecr2018/C-1652
Methods and materials
Initially,
33 patients had their liver qualitatively assessed using using lab test and ultrasound liver examination.
The patient underwent a 3T high resolution MRI which included T1 weighted sequences with in-phase, out-of-phase and fat specific phases,
T2-weighted and spectroscopy sequences. The qualitative assessement was made using the Fat-Fraction calculated manually after spectroscopy computer analysis.
Fat-Fraction = Lipid area/(Lipid area + H2O area) x 100
25 patients were surgically treated for a different pathology and a liver biopsy was sampled and histologically analysed.
The steathosis was graded as follows:
- grade 0 (normal) = up to 10% of cells affected;
- grade 1 (low/mild) = 10–33% of cells affected;
- grade 2 (moderate) = 34–66% of cells affected;
- grade 3 (severe) = ≥67% of cells affected.