The results of the RD can find an explanation in the properties of the HA+SA combination to influence on the skin metabolic (plastic and energy) processes and the hydrophilicity of the ECM.
One of the SA key point is the ability to block reactive oxygen species (ROS).
SA shows antioxidant activity .
As is known,
ROS are the basis of the theory of skin aging (Inflamejding).
The HA+SA mixture has a positive effect on the control of the clinical inflammation,
which is proved by the subjective and objective measurement of swelling and erythema levels.
[ 9,
17,
18,
19].
Thus,
today it is possible to consider the SWE as an instrument for an objective quantitative assessment of the mechanical properties of the dermis itself and the subcutaneous fat layer.
The use of SWE is described in normal/pathological conditions and in case of skin damage to various etiologies,
as well as during plastic and surgical operations,
cosmetic procedures [ 9,
20,
21,
22,
23].
However,
it is necessary to take into account a number of restrictions when using skin 2D-SWE [1,
14,
15].
The surface location of the skin leads to its additional compression (precompression) with an US probe. Precompression can lead to an overestimation of the results of measuring the stiffness of the dermis.
Another limitation of skin elastography is the presence of a “dead zone” in skin layers under the probe.
It is important to avoid reverberation artifact from strong reflectors under the skin,
such as bones,
tendons,
and cartilage.
Since elastography appeals to the information contained in the connective tissue of the skin (ECM,
collagen fibers and HA),
it is logical to use Real-time 2D-SWE as a tool for objectifying the effect of Hyalual booster intradermally injection (combination HA 22 mg/ml and SA 16 mg/ml) on the mechanical properties of the dermis during RD.
1. Real-time 2D-SWE of the skin is available as a routine procedure with the ability to control quality elasto-visualization and eliminate elasto-artifacts: precompression,
reverberation and the "dead zone".
2.
The course of redermalization with a HA+SA combination did not change of the thickness but increase of the dermis elasticity of the rear wrists and cheeks.