Keywords:
CNS, Neuroradiology brain, Oncology, MR, MR-Diffusion/Perfusion, Computer Applications-Detection, diagnosis, Neoplasia
Authors:
M. Talaat1, A. A. A. Abdel Razek2, G. Gaballa2, L. Elserougy2; 1Kafr El Sheikh/EG, 2Mansoura/EG
DOI:
10.26044/ecr2019/C-0926
Methods and materials
Patients
This prospective study was approved by the local ethics committee and full written consents were obtained from all patients prior to the examination.
The study included 36 patients provisionally diagnosed to have intra-axial glioblastoma or brain metastasis based on conventional MR imaging.
MRI imaging
The MR imaging was performed using a 1.5 Tesla scanner.
First non contrast study was done,
including (T1,
T2 & FLAIR sequences),
then post IV contrast T1-weighted MR images study is done using gadoterate meglumine.
The ASL perfusion imaging was performed with pseudo-continuous labeling.
Multiple time points acquired after the label pulse.
The DICOM images were transferred to workstation.
The post processing of arterial spin-tagging data typically involves subtraction of label and control images.
The regions of interest (ROIs) were placed within tumor and peritumor regions (within 1cm from margin of enhanced tumor).
DTI data were obtained using a single-shot echo planar imaging sequence.
Firstly automated registration of the DTI data was done to eliminate eddy current artifacts.
the fraction anisotropy (FA) and mean diffusivity (MD) of the enhancing tumor parts and the immediate peri-tumor region (within 1 cm of the enhancing outer tumor margin) were measured.
Statistical analysis
Statistical analyses were carried out.
Quantitative data were presented as mean ± standard deviation (SD).
Normally distributed data were compared between the two major groups using independent samples t test.
Data which violated the normality assumptions were compared using Mann-Whitney test.
Probability (P) values < 0.05 were considered statistically significant.
The receiver operating characteristic (ROC) curves of different matrices of the tumor and peri-tumor regions were done with calculation of the area under the curve.