Keywords:
Cardiac, CT, CT-Quantitative, Computer Applications-3D
Authors:
E. Conte, S. Mushtaq, M. E. Mancini, A. D. Annoni, A. Formenti, M. Guglielmo, G. Muscogiuri, G. Pontone, D. Andreini; Milan/IT
DOI:
10.26044/ecr2019/C-1071
Methods and materials
A consecutive cohort of patients with newly diagnosed LVD (left ventricular disfunction) (LVEF<50%) and clinical indicated MRI will be screened.
Exclusion criteria will be contraindications to contrast agents and impaired renal function (creatinine clearance <60 ml/min).
Cardiac CT will be performed per protocol within ±10 days from MRI.
CCTAs will be performed with last generation CT scanner with whole heart coverage and gantry rotation time of 280 msec.
A first CT scan will be performed using bolus tracking technique and timing for the scan will be targeted to obtain a good contrast enhancement of both left and right ventricles in order to obtain raw data suitable for the calculation of volumes and function of both ventricles (the entire cardiac cycle will be included in the acquisition).
After 8 minutes from contrast medium injection a second CT scan will be performed for myocardial late-enhancement detection.
Cardiac MRI will be performed using standard clinical protocol.
Cardiac CT and cardiac MRI findings will be compared for what concerned biventricular volumes and function and for myocardial fibrosis detection.
Moreover,
the capability to identify LVD etiology with cardiac CT (ex: ischemic vs non-ischemic) will be compared with cardiac MRI.
In those patients in which ICA will be performed diagnostic accuracy vs cardiac CT will be evaluated.
Finally,
cardiac vein anatomy will be evaluated in every patients.
Radiation dose and adverse events will be recorded for every patients.