Type:
Educational Exhibit
Keywords:
Pathology, Metabolic disorders, Congenital, Molecular imaging, Imaging sequences, Contrast agent-intravenous, MR-Spectroscopy, MR-Diffusion/Perfusion, MR, Paediatric, Neuroradiology brain, CNS
Authors:
S. P. Gowdar; Bangalore /IN
DOI:
10.26044/ecr2019/C-1083
Conclusion
Out of 12 patients 7 were diagnosed leukodystrophies,
4 were leukoencephalopathies and 1 hypomyelination.
Leukodystophies:
- Metachromatic leukodystrophy
- Adenoleukodystrophy
- Canavan disease
- Krabbe disease
- Alexanders disease
- Leigh’s disease
- Non-specific leukodystrophy
|
Leukoencephalopathies:
- Periventricular leukoencephalopathy
- Megaloencephalic Leukoencephalopathy
- Cavitating Leukoencephalopathy
- Vanishing white matter disease
|
MRI has become the primary imaging modality in patients with leukodystrophy and plays an important role in the identification,
localization,
and characterization of underlying white matter abnormalities in affected patients.
Although the mr imaging features of leukodystrophy are often nonspecific,
systematic analysis of the finer details of disease involvement may permit a narrower differential diagnosis,
which the clinician can then further refine with knowledge of patient history,
clinical testing,
and metabolic analysis.
Fig. 1