Keywords:
Liver, Oncology, MR physics, MR, Contrast agent-intravenous, Physics, Imaging sequences, Neoplasia
Authors:
M. Ippoliti, C. Kolbitsch, T. Schaeffter, A. Baur, M. R. Makowski; Berlin/DE
DOI:
10.26044/ecr2019/C-2048
Results
Respiratory motion and related artefacts impaired vessel and lesion detectability and led to misalignment between neighbouring temporal dynamics,
strongly impairing the quantitative assessment of the pharmacokinetic uptake model (Toft’s model).
With the proposed motion correction scheme,
the average CNR measured over a set of 19 metastases,
could be improved by 47% compared to the non-motion corrected images and ensured high image quality for each dynamic with accurate temporal alignment over the entire 5 min acquisition period.
Statistical significance (p<0.001) was reached in the paired sample t-test.
The parametric maps representing the endothelial permeability (Ktrans) derived from fitting the pharmacokinetic model,
for both Primovist (Figure 3) and Gadovist (Figure 4) data,
also show an increase in the contrast of small features and metastases.