Type:
Educational Exhibit
Keywords:
Abdomen, CT, Cholangiography, Neoplasia
Authors:
N. jurjevic1, L. Kavur2, L. Ištvanović2, F. Matijević2, V. Vidjak2; 1Rijeka/HR, 2Zagreb/HR
DOI:
10.26044/ecr2019/C-2594
Background
Cholangiocarcinoma is an epithelial cell malignancy arising from varying locations within the biliary tree showing markers of cholangiocyte differentiation.
The most contemporary classification based on anatomical location includes intrahepatic (iCCA),
perihilar (pCCA),
and distal (dCCA) cholangiocarcinoma,
exclusive of gallbladder and ampulla of Vater.1 The incidence of iCCA appears to be increasing and may be as high as 2.1 per 100,000 person years in Western Countries.2
iCCA may occur in patients with normal liver or with underlying liver disease,
and in either clinical context usually is classified pathologically as an adenocarcinoma,
although mixed hepatocellular – cholangiocarcinomas also occur,
especially in chronic liver disease.3
Surgical treatment is the preferred option for all subtypes,
even though it’s highly desmoplastic nature,
extensive support by a rich tumor microenvironment,
and profound genetic heterogeneity contribute to its therapeutic resistance.1