Molecular imaging, Nuclear medicine, Oncology, PET-CT, Cancer, Biological effects
M. V. Knopp1, E. D. Miller2, K. Binzel1, T. M. Williams1, P. Kneuertz2, M. Welliver2, M. I. Knopp1, C. L. Wright1, J. Zhang1; 1Columbus, OH/US, 2Columbus/US
Aims and objectives
Dynamic PET perfusion imaging (DPPI),
despite its long history,
has become a forgotten technique as clinical perfusion imaging moved to dynamic contrast enhanced MRI and CT.
We intend to redevelop DPPI using next-generation digital PET technology and focus in this Phase I study on thoracic applications.
Next generation digital PET facilitates the clinical use of dynamic acquisition as short whole-body tables times enable more patients to be imaged per hour than typically injection suites are available.
Therefore we envision the comprehensive PET examination of the future to be of 10 min total table time,
5 min for perfusion and 5 min for whole-body PET imaging. Perfusion characteristics are known to give important insights into lesion characteristics as had been established with 15O water studies as well as DCE MRI.As no additional tracer is needed,
there are no increased cost even with full clinical PET scanner utilization.