Prediagnostic CT and MR may show pitfalls and subtle findings suggestive of indolent early detection of PDA and malignant IPMN. The most common findings are focal hypoattenuating lesion, pancreatic duct dilatation and/or interruption, associated with pancreatic tail atrophy. Radiologist confidence in the acknowledgment of early, indirect signs of neoplastic lesion has a leading role in the multidisciplinary decision of surgical resectability of a pancreatic lesion.