Neuroblastoma is a pediatric tumor of relatively high frequency. Certain cases of occult neuroblastoma can present with the opsoclonus-myoclonus syndrome. In these cases, diagnosis of neuroblastoma requires the I-MIBG scan for proper detection of primary and secondary tumors, as urine and serum catecholamine levels can often be normal. The I-MIBG scan is highly specific and sensitive in detecting neuroblastoma and should be considered the test of choice by radiologists in screening procedures. This test will allow for efficiency in diagnosis and treatment of these pediatric patients.