Keywords:
Artificial Intelligence, CT, Computer Applications-General, Outcomes
Authors:
J. Pan, K.-H. Nenning, S. Röhrich, N. Sverzellati, V. Poletti, J. Hofmanninger, A. Makropoulos, H. Prosch, G. Langs
DOI:
10.26044/ecr2023/C-14403
Results
Our study included a cohort of 55 IPF patients, among whom 21 patients passed away before the censoring date, and the average time between their scans and death was 18.9 months. The remaining 34 patients had a censoring data on average 73.9 months after the scans. Our analysis revealed that both the static and dynamic signature patterns were significantly associated with patient survival. Specifically, we found that the honeycombing and consolidation patterns were significantly associated with survival, with a hazard ratio of 5.39 and 5.35, respectively, and a p-value less than 0.01. The mean volume was calculated to be 0.07% for honeycombing and 0.005% for consolidation. Our findings suggest that the presence of honeycombing and consolidation patterns in CT scans may be indicative of poorer survival outcomes in IPF patients.
Moreover, our analysis of the dynamic signature patterns showed that only the consolidation pattern was significantly associated with survival, with a hazard ratio of 2.77 and a p-value of less than 0.03. This finding could suggest an association with pleuroparenchymal fibroelastosis.