Keywords:
Vascular, Arteries / Aorta, Musculoskeletal soft tissue, MR-Diffusion/Perfusion, Contrast agent-intravenous, Arteriosclerosis, Ischaemia / Infarction
Authors:
N. Sinkevich, E. Butorova, O. Stukalova, M. Maslennikov, O. Bulkina, S. K. Ternovoy, Y. Karpov; Moscow/RU
Results
Mean ABI after 6 months follow up was 0.68±0.19 and didn’t differ significally from the initial (p=0.13).
All patients were divided in two groups due to ABI level.
Group 1 presented with ABI increase for 0,04 and more and consisted of 16 patients (70%).
Group 2 (n=9) showed ABI decrease or the same as initial.
Group 1 showed no changes in MRI tissue perfusion measures (p>0.05) The data presented in table 2 (Figures 3-5).
|
Initial
|
Follow-up
|
р
|
Rest ABI
|
0.58±0.16
|
0.75±0.18
|
0.005
|
Exercise ABI
|
0.49±0.18
|
0.66±0.18
|
0.0015
|
Delta ABI
|
-0.08 [-0.125; -0.04]
|
-0.075 [-0.122; -0.048]
|
0.9
|
Pain-free walking distance,
m
|
108[79.3; 160]
|
214.2 [94.2;318]
|
0.0046
|
Absolute walking distance,
m
|
316[197; 432]
|
505.9 [282; 623.6]
|
0.0017
|
Rest MP
|
6.44±3.29
|
6.75±1.85
|
0.45
|
Exercise MP
|
9.1±4.45
|
8.8±2.3
|
0.7
|
Time-to- peak exercise MP
|
38.3±7.9
|
35.8±7.6
|
0.09
|
Time-to- peak rest AIF
|
37.8±7.06
|
40±8
|
0.14
|
Time-to- peak exercise AIF
|
35.9±9.35
|
35.8±7.63
|
0.9
|
Table 2.
Group 1,
initial data compared to follow-up.
Group 2 characteristic is showed in table 3.
Patients from the second group presented with significant exercise tissue perfusion decrease (9.3±2.8 vs 11.56±2.9,
p=0.0039,
figure 3).
Time-to-peak exercise skeletal muscle perfusion was significally higher than the initial (44.78±11.3 vs 37.2±6.67,
p=0.0333,
figure 4). Also,
arterial input flow in group 2 reached the peak values significally slower compared to the initial data (48.8±6.5 vs 37.2±5.06,
p=0.0139,
figure 5).
|
initial
|
Follow-up
|
р
|
Rest ABI
|
0.62±0.09
|
0.54±0.14
|
0.03
|
Exercise ABI
|
0.56±0.11
|
0.48±0.15
|
0.0117
|
Delta ABI
|
-0.05 [-0.1; -0.04]
|
-0.05 [-0.125; 0.02]
|
1
|
Pain-free walking distance,
m
|
114 [63.7; 145.5]
|
104.6 [80.5; 330]
|
0.46
|
Absolute walking distance,
m
|
310 [243; 430]
|
281.6 [173; 469]
|
0.9
|
Rest MP
|
5.54±2.49
|
6.1±2.5
|
0.46
|
Exercise MP
|
11.56±2.9
|
9.3±2.8
|
0.0039
|
Time-to- peak exercise MP
|
37.2±6.67
|
43.88±10.4
|
0.0333
|
Time-to- peak rest AIF
|
41.1±6.5
|
48.13±13.08
|
0.17
|
Time-to- peak exercise AIF
|
37.2±5.06
|
48.8±6.5
|
0.0139
|
Table 3.
Group 2,
initial data compared to follow-up