Keywords:
Tissue characterisation, Neoplasia, Laboratory tests, Biopsy, MR, Musculoskeletal soft tissue
Authors:
S. Al-Qassab, P. Suresh, L. Farmkiss, K. Syred; Plymouth/UK
DOI:
10.26044/essr2019/P-0163
Results
Total number of patients with atypical lipomas referred to the Peninsula Sarcoma MDT between August 2017 and September 2018 and had MDM2 tested were 23; sixteen from Plymouth,
and seven from Cornwall.
Seven lesions were MDM2 positive.
However,
two cases were excluded:
1 MDM2 not performed
1 recurrent mesenteric liposarcoma (MDM2 +ve)
The total number after exclusions= 21.
The 21 lesions were divided into retroperitoneal and non-retroperitoneal.
Fig. 13: Distribution of retroperitoneal and non-retroperitoneal lesions.
References: Authors
The non-retroperitoneal were further categorised based on the anatomy into extremity lipomas (10) and torso lipomas (6).
They were also categorized according to location into subfascial and intramuscular lesions.
One of the extremity lesions did not have any imaging.
Fig. 12: Anatomical distribution of the lesions.
References: Authors
MDM2 results were positive in 6 out of the 21 lesions.
Fig. 11: MDM2 positive cases distribution.
References: Authors
All four of the non-retroperitoneal MDM2 positive lesions were intramuscular (3 extremities and 1 torso) and none of the subfascial lesions were MDM2 positive.
Fig. 10: MDM2 positive in the non-retroperitoneal lesions.
References: Authors
None of the grade 1 lesions on MRI were MDM2 positive.
Two of the retroperitoneal lesions were MDM2 positive.
Fig. 9: MDM2 results in the retroperitoneal lesions.
References: Authors