ESTI 2019 / P-0055
Significance of baseline CT assessment for predicting the pulmonary fibrosis during the course of chemotherapy-induced pneumonitis
Keywords:
Drugs / Reactions, Cancer, Complications, Chemotherapy, CT, Thorax, Lung
Authors:
J.-Y. Han, J. W. Baek, K.-N. Lee, S. J. Choi; Busan/KR
DOI:
10.26044/esti2019/P-0055
Conclusion
Summary
- In this study,
we described the factors for the development of pulmonary fibrosis in the baseline CT during the course of CIP.
Our study showed that CT findings of fibrosis remained in 32.5% of the patients with CIP.
Preexisting ILD and moderate to severe emphysema were significant risk factors for developing fibrosis in CIP.
Moderate to severe emphysema was a significant risk factor for developing severe fibrosis over 11% in extent in our study.
Limitation
- Diagnosis of the pattern of ILD was based on CT findings and medical records without described lung histopathology.
- Only a few patients were treated with a single agent.
The causative agent of CIP was difficult to elucidate in combination chemotherapy.
Conclusion
- Follow-up CT assessment might be the only method to evaluate the development of pulmonary fibrosis.
- Baseline CT might help evaluating the risk factors for developing pulmonary fibrosis in patients with CIP.