ESTI 2019 / P-0055
Significance of baseline CT assessment for predicting the pulmonary fibrosis during the course of chemotherapy-induced pneumonitis
Keywords:
Drugs / Reactions, Cancer, Complications, Chemotherapy, CT, Thorax, Lung
Authors:
J.-Y. Han, J. W. Baek, K.-N. Lee, S. J. Choi; Busan/KR
DOI:
10.26044/esti2019/P-0055
Methods & Materials
Patient characteristics
- Patient selection and exclusion are demonstrated in Figure 1.
- Reviewed demographics,
underlying malignancies,
chemotherapeutic agent,
exposure duration,
preexisting ILD and past history of CIP
CT Analysis
- Brilliance iCT (Philips) / 2mm thickness without a gap
- CIP was categorized into 4 patterns:
Usual interstitial pneumonia (UIP),
probable UIP,
indeterminate for UIP and non UIP in accordance with the ATS/ERS/JRS/LATAS Statement
- Extent of fibrosis ; on axial scan individually in terms of a 5% volumetric score for 6 zones (Figure 2)
- Radiologic risk factors
lung cancer,
pulmonary metastasis,
preexisting interstitial lung disease (ILD),
moderate to severe emphysema and number of normal lobe
Statistical Analysis
- Interobserver and intraobserver variability
Intraclass correlation coefficients (ICC)
- Univariate and multivariate analyses
Risk factors for development of fibrosis and fibrosis over 11% in extent
- SPSS version 18.0 (SPSS Inc,
Chicago,
IL)