Keywords:
Lung, CT, Screening, Occupational / Environmental hazards
Authors:
J. Teh, P. Wong, C. P. Murray, Y.-J. Kuok, N. de Klerk, H. Alfonso, A. Reid, A. W. Musk, F. J. Brims; Perth/AU
DOI:
10.1594/ranzcr2015/R-0062
Results
A total of 143 cases with paired ultra-LDCT and DLCO results were included in the study.
The demographic data of participants is presented in Table 1.
The cases consisted of 130 males and 13 females,
with a mean age of 72 years ± 9.7 (range 49 to 92 years).
Inter-observer agreement regarding the presence of ILD was excellent (k = 0.95).
No evidence of ILD was shown in 80 (56%) participants; 25 (17%) were equivocal for ILD; and 38 (27%) had ILD.
The correlation between ILD scores and DLCO was significant and strong,
with a Spearman's rank correlation coefficient of -0.3345,
p<0.0001 (Fig 1).
Figures 2 to 4 highlight key ultra-LDCT findings associated with progressive fibrosis scores.
In Figure 5,
progressive pulmonary physiologic derangement,
as evidenced by worsening restrictive ventilatory defect and lower DLCO values on PFTs corresponded with increasing radiographic abnormalities of ILD.