2021 ASM / R-0283
The role of SUV measured on 18F-FDG PET/CT in follicular lymphoma versus diffuse large B-cell lymphoma: a retrospective review
Keywords:
Nuclear medicine, PET-CT, Molecular imaging, Lymphoma
Authors:
T. Skalina, J. Blazak; Sunshine Coast, QLD/AU
DOI:
10.26044/ranzcr2021/R-0283
Methods and materials
Patient population
- A retrospective review of 97 patients with a histological diagnosis of lymphoma that underwent TOF 18F-FDG PET/CT examinations between January 2018 and December 2019 was undertaken.
- A total of 56 patients (58 lymphomas) satisfied inclusion and exclusion criteria.
PET/CT imaging and SUV measurement
- All patients fasted for 6 hours prior to TOF 18F-FDG PET/CT examinations.
- Blood glucose levels were confirmed to be less than 11.0mmol/L.
- Images were acquired on an integrated PET/CT scanner (Biograph mCT Flow Edge; Siemens Medical Solutions, USA) 60 minutes after intravenous administration of 18F-FDG (3.2 MBq/kg, min 150 MBq up to 320 MBq).
- We used a torso protocol with PET acquisition from the cranial vertex to mid-thigh.
- Quantitative analysis of 18F-FDG uptake using SUVmax was performed using Syngo Via software package (Siemens Healthcare GmbH, Germany) at the site of biopsy.
Statistical analysis
- Statistical analyses were performed using R (version 4.0.2, Vienna, Austria).
- Descriptive statistics are presented using median and inter-quartile range (IQR) and count (%).
- Boxplots were used to visually compare the SUVmax of the biopsied lesion between DLBCL and FL. Normality was assessed using the Shapiro-Wilk test.
- To evaluate the optimal cut-off for the SUVmax in predicting DLBCL versus FL, we used Receiver Operating Characteristic (ROC) curve analysis and the Youden’s index.
- Significance between NHL sub-type and SUVmax at various thresholds (<10, 10-15, >15) was determined using Chi square tests with P <0.05 considered statistically significant.