2021 ASM / R-0283
The role of SUV measured on 18F-FDG PET/CT in follicular lymphoma versus diffuse large B-cell lymphoma: a retrospective review
Keywords:
Nuclear medicine, PET-CT, Molecular imaging, Lymphoma
Authors:
T. Skalina, J. Blazak; Sunshine Coast, QLD/AU
DOI:
10.26044/ranzcr2021/R-0283
Results
- A total of 56 patients were included (58 lymphomas).
- The median age was 67.5 years (62.8–75 years); 51.79% were female; 31 (53.45%) of the NHLs were DLBCL and 27 (46.55%) were FL.
- The median SUVmax for DLBCL was 18.37 (IQR:11.80, 28.42) and for FL was 10.98 (IQR: 6.96, 13.65) (Figure 1 and 3a).
- There was a statistically significant difference (p=0.005) in the SUVmax between NHL subtypes where the majority of patients with an SUVmax <10 and 10-15 were FL patients (63.16% and 69.23% respectively) and a higher proportion of patients with an SUVmax >15 were DLBCL (76.92%) (Figure 2).
- ROC curve analysis determined an SUVmax of 14 as the most balanced cut-off between DLBCL and FL (≥14 classified as DLBCL; <14 was FL) (Figure 3b).
- This cut-off gave an area under the curve of 0.750 (95%CI: 0.585, 0.902), sensitivity of 0.710 (95%CI: 0.550, 0.869) and a specificity of 0.778 (95%CI: 0.621, 0.935) with 74.1% accuracy.