The main goal of this study is: To describe the radiologic findings of primary brain lymphoma (PBL). To illustrate the typical and atypical advanced MR imaging features of PBL. To know differential diagnosis of PBL.

PBL is defined as lymphoma in the central nervous system (CNS) without primary tumor elsewhere. It is less common than secondary CNS involvement by systemic lymphoma. PBL causes approximately 5% of all primary brain tumors [1]. PBL is a diffuse large B-cell lymphoma in 90% of cases and is usually high grade. Less common PBL histological types are Burkitt’s lymphoma and T-cell lymphoma. PBL occurs sporadically or in association with congenital or acquired immunodeficiency disorders. A remarkable increase of PBL incidence was observed in the...

Patients Prospective study of 11 patients with PBL proven histologically, enrolled in our University Hospital center from January 2009 to December 2011. All the patients were immunocompetent. The mean age was 53 years. In other publications, PBL usually occurred in the sixth decade [5]. They had a variety of symptoms including : Signs of increased intracranial pressure (n=8), focal neurological deficits (n=5), and signs of Coma (n=3). Imaging analysis (our study) MRI study of the brain was performed in all the patients either immediately or...

CNS lymphomas may have a characteristic appearance on traditional CT and MR imaging; however, none of these imaging characteristics will unequivocally differentiate CNS lymphomas from other neoplasms (eg, metastases from other malignancies, malignant gliomas, meningiomas) or non-neoplastic diseases (eg, multiple sclerosis, stroke, cerebral toxoplasmosis, pyogenic abscess). Furthermore, the typical imaging characteristics may not be present. DWI, perfusion MR imaging, and MR spectroscopy are increasingly used in clinical radiologic practice and may help to differentiate CNS lymphomas from other lesions of the brain. Stereotactic biopsy performed...

Tang YZ, Booth TC, Bhogal P, Malhotra A, Wilhelm T. Imaging of primary central nervous system lymphoma. Clin Radiol, 2011 Aug;66(8):768-77. Bashir R, Luka J, Cheloha K, et al. Expression of EpsteineBarr virus proteins in primary CNS lymphoma in AIDS patients. Neurology1993; 43:2358 e62. Morgello S, Petito CK, Mouradian JA. Central nervous lymphoma in the acquired immunodeficiency syndrome. Clin Neuro pathol 1990; 9 :205e15. Gliemroth J, Kehler U, Gaebel C, Arnold H, Missler U. Neuroradiological findings in primary cerebral lymphomas of non-AIDS patients. Clin Neurol...

Alaoui Lamrani Youssef Radiology Departement CHU Hassan II Fès. Maroc