Diffusion-Weighted MRI at 3 T for the Evaluation of Prostate Cancer

Congress:

ECR 2013

Poster Number:

C-0483

Type:

Educational Exhibit

Keywords:

Genital / Reproductive system female, MR-Diffusion/Perfusion, Diagnostic procedure, Neoplasia

Authors:

M. Recio¹, C. Lopez², P. Redondo Buil¹, N. Sanchez Rubio¹, A. Maldonado¹, L. Herraiz Hidalgo³, A. Alvarez Vazquez², C. Hayoun¹, A. Fernández¹; ¹Pozuelo de Alarcón/ES, ²Pozuelo de Alarcón, So/ES, ³POZUELO, MADRID/ES

DOI:

10.1594/ecr2013/C-0483

DOI-Link:

https://dx.doi.org/10.1594/ecr2013/C-0483

Fig. 1: Fig. 1: Pulse sequence diagrams illustrate how a diffusion-weighted sequence...

Fig. 2: Fig. 2: Restriction in the diffusion of water molecules is directly...

Fig. 3: Fig. 3: A. DWI. B. Exponential image. High signal area in left peripheral zone....

Fig. 4: Fig. 4:PC T2A. Axial FSE T2. Focal low signal in the peripheral zone on the...

Learning objectives

Learning objectives: To illustrate the basic concepts for the biologic basis of DWI, illustrates its potential clinical applications at 3 T, and discusses its current limitations and future directions.

Background

Introduction Diffusion-weighted MRI (DWI) has been applied to extracranial sites since the 1990s (1). The advent of echo-planar imaging (EPI), high-gradient amplitude and multichannel coils, and parallel imaging have been instrumental in allowing fewer motion artifacts and high-quality prostate images. The acquisition time of DWI in the prostate is short, and it does not need the administration of contrast media. Thus, DWI can be included easily in routine imaging protocols. We review the basic concepts for the biologic basis of DWI and techniques of prostate...

Imaging findings OR Procedure details

Basic concepts for the biologic basis of DWI and techniques of prostate 3-T DWI. DWI depends on the microscopic mobility of water. This mobility, classically called Brownian motion, is due to thermal agitation and is dependent on the cellular environment of water (2). Bulky fluids in the body (such as the urinary bladder or gallbladder) show free and isotropic diffusion. In biologic tissues, however, water diffusivity is restricted by different components, such as tissue cellularity, tissue organization, extracellular space tortuosity, and the integrity of cell...

Conclusion

Diffusion-weighted imaging (DWI) is a powerful noninvasive imaging method that may yield useful qualitative and quantitative information about tumor cellularity and tissue structure in prostate cancer and permits detecting and staging prostate carcinoma. A pretreatment combination of tumor ADC, Gleason score and baseline PSA level might play an important role in risk staging for prostate cancer treatment, which could improve the cancer control while reducing risks of treatment-related complications. This would lead to a major change beyond the role of MR imaging such as tumour...

References

REFERENCES Koh DM, Collins DJ. Diffusion-weighted MRI in the body: applications and challenges in oncology. AJR 2007; 188:1622–1635. Le Bihan D. Diffusion/perfusion MR imaging of the brain: from structure to function. Radiology 1990; 177:328–329. Jacobs MA, Ibrahim TS, Ouwerkerk R. AAPM/RSNA Physics Tutorial for Residents: MR imaging: brief overview and emerging applications. Radiographics 2007; 27(4):1213-29. Poustchi-Amin M, Mirowitz SA, Brown JJ, McKinstry RC, Li T. Principles and applications of echo-planar imaging: a review for the general radiologist. Radiographics 2001;21(3):767-79. Koh D, Collins DJ. Diffusion-weighted MRI...