Aims and objectives
The purpose of this study is to assess the efficiency of sonoelastography in the determination of the presence and degree of liver fibrosis and to examine whether there are diagnostic differences between intraparenchymal venous vascular structure / liver parenchyma rate (VPR) and intercostal muscle / liver parenchyma rate (MPR),
to assess the compatibility between these two methods and to determine which of these two methods is more reliable.
Methods and materials
The study group consisted of cases that were found to have liver disease and sent to the department of Radiology for percutaneous liver biopsy by different clinics between December 2012 and June 2013.
Approval was taken from the hospital’s ethics committee for this prospective study.
Informed consent form was taken from all cases.
Sonoelastographic assessment was made before percutaneous liver biopsy.
Two different strain rates VPR and MPR were found via sonoelastography.
These rates were recorded to be compared with histopathology results.
Based on the...
Results
The study included 59 cases (29 women,
30 men,
average age 45±15 years) who had percutaneous liver biopsy.
As a result of the histopathological assessment,
6 (%10.2) of the cases were reported to be F0,
28 (%47.5) of the cases were reported to be F1,
20 (%33.8) of the cases were reported to be F2 and 5 (%8.5) of the cases were reported to be F3.
Average strain rates were as follows for VPR; F0 (2.83 ± 0.45),
F1 (3.78 ± 0.47),
F2 (4.69 ±...
Conclusion
Sonoelastography is a screening method which has a high efficiency in assessing liver fibrosis.
There is a high concordance between VPR and MPR and VPR has more reliable values in the diagnosis of severe fibrosis.
References
1- Rossi E,
Adams LA,
Bulsara M,
Jeffrey GP.
Assessing liver fibrosis with serum marker models.
Clin Biochem Rev 2007;28:3-10.2- Afdal NH,
Nunes D.
Evaluation of liver fibrosis a concise rewiev.
Am J Gastroenterol.
2004;99(6):1160-74.3- Bravo A,
Sheth SG,
Chopra S.
Liver biopsy.
N Eng J Med.
2001;344:495-500.4- Mohamadnejad M,
Montazeri G,
Fazlollahi A,
Zamani F,
Nasiri J,
Nobakht H ve ark.
Noninvasive markers of liver fibrosis and inflammation in chronic hepatitis B-Virus related liver disease.
Am J Gastroenterol 2006;101:2537–45.5- Koizumi Y,
Hirooka M,
Kisaka...