To investigate whether and in which manner different phenotypic characteristics influence false-positive breast cancer (BC) screening results after arbitration for digital breast tomosynthesis (DBT) compared to digital mammography (DM) by using a statistical approach.

The Malmö Breast Tomosynthesis Screening Trial was designed to compare the performance of one-view DBT to two-view DM in BC screening [1]. We analysed the data corresponding to the first half of the study population (n= 7 500). In order to determine which women had cancer a linkage with the Swedish Cancer Registry was used with a follow up period of at least 1 year from the screening visit. By using classification and regression trees (C&RT), we estimated the recall probability for different groups of...

In order to obtain a simple classification scheme to predict which groups of women that would be recalled a C&RT is calculated. The results are shown in Figure 1. By using DBT, 98.5 % (92.1 %, 100.0 %) of screened women with BC would be recalled for further examinations. In the case of DM 69.1 % (56.7 %, 79.8 %) of cancer cases would be detected. The recall of healthy women is mainly affected by breast density for both methods. The probability of a false-positive...

The probability of a false-positive BC screening result is mostly affected by breast density and it increases with breast density for DBT and DM. The expected number of false-positive BC cases is higher for BT compared to DM. The largest difference of false-positive cases between the two methods is observed in dense breasts. Thus, the implementation of DBT in screening may give more false-positive cases than DM mostly for women with dense breasts. DBT images generally show more normal tissue structures and benign lesions compared...

Aldana M. Rosso, Ph.D., Epidemiology and Register Centre South, Skåne University Hospital, Lund, Sweden; [email protected] Ingemar F. Petersson, M.D. Ph.D. Professor, Epidemiology and Register Centre South, Skåne University Hospital, Lund, Sweden; [email protected] Kristina Lång, M.D., Department of Medical Radiology, Clinical Sciences Malmö, Lund University, Malmö,Sweden; [email protected] SophiaZackrisson, M.D. Ph.D., Department of Medical Radiology, Clinical Sciences Malmö, Lund University, Malmö,Sweden; [email protected]

1. K. Lång, I. Andersson, A. Rosso, A. Tingberg, P. Timberg, S. Zackrisson. Performance of one-view digital breast tomosynthesis versus two-view mammography in breast cancer screening - First results from the Malmö Breast Tomosynthesis Screening Trial. To be published.