Early identification of Breast Cancer (BC) through mammography screening programs of general population is amply demonstrated in several studies conducted over the past years, that report a reduction in mortality of about 22% for women aged 50-69 years old [1,5]. Actually Mammography (MMG), although not perfect, can be considered the main screening test in order to detected early BC with a sensitivity of 75%-85% calculated in general population [2], up to 80%-98% in women with fat breast tissue (ACR D1-D2) [3]. Less promising results have...

At the Center of Breast and Ovarian Familiar Tumors in Modena, 3306 women considered at increased familiar risk for BC were enrolled in a surveillance program from January 1994 to June 2014 and divided into four risk categories depending on familiar history or BRCA status according to Modena Criteria: BRCA mutation carriers (BRCA+), High, Intermediated andSlightlyincreasedrisk (Fig.1). Clinical Breast Examination (CBE), MMG, US and MR are performed annually by experts radiologists of about 10-20 years of breast imaging experience at our dedicated clinic located at...

After a median follow up of about 11 years, 150 cancers were diagnosed on 148 patients, of these 134/150 (89%) were Screen Detected Breast Cancers (SDBC), while 16/150 (11%) were Interval Breast Cancer (IBC). Of 134 SDBC 32 (24%) were detected by US alone, 95 (71%) by MMG alone or plus US, 7 (5%) by MR (Fig.3-4); 60,4% in High risk group and 17,2% in BRCA+ group; patients ages ranged from 32 to 87 years; 43% below age 50 years, while 57% aged ≥50. Of...

MMG is a recommended imaging modality for detection of BC in general population, although with a sensitivity that progressively and greatly decreases in a proportional way according to the increment of breast density [10] with low performance for young women where the added value of MMG is very low [12]. In women aged 30-39 years who manifest clinical symptoms, breast US should be the primary imaging approach, while MMG represents the first modality in the older group [12]. In high risk population MMG alone is...

J.H. Youk, MD, E.K. Kim, MD Supplementary Screening Sonography in Mammographically Dense Breast: Pros and Cons. Korean J Radiol, 2010;11(6). M.S. Bae, MD, W.K. Moon, MD, J. M. Chang, MD et al. Breast Cancer Detected with Screening US: Reasons for Nondetection at Mammography. Radiology February 2014;270:2. R.J. Hooley, MD, K.L. Greenberg, DO, R.M. Stackhouse, MD et al. Screening US in Patients with Mammographically Dense Breasts: Initial Experience with Connecticut Public Act 09-41. Radiology October 2012;265:1. American College of Radiology. ACR BI-RADS-Mammography. ACR Breast imaging Atlas...