Aims and objectives
The purpose of this study was to use serial magnetic resonance imaging (MRI) examinations to observe changes in malignant lung tumors over time post-cryoablation.
Methods and materials
Patients with primary or metastatic lung tumors eligible for cryoablation were included in this prospective study.
Cryoablation was performed according to standard procedures.
Unenhanced and dynamic contrast-enhanced MRI scans were performed pre-cryoablation and at 1 day,
1 week,
and 3-,
6-,
and 12 months after cryoablation.
At each time point,
the signal intensity of the ablated zone on both T1WI and T2WI images,
and volume and characteristics of the ablation zone were examined,
and changes over time analyzed.
Results
A total of 26 nodules in 23 patients were included in the study.
The mean patient age was 53.7 ± 13.6 years,
and 57.7% were males.
Ablation zone volume increased to 1 week after the procedure,
and then returned to baseline by 3 months.
Cavitation post-cryoablation was found in 34.6% (9/26) of the nodules 1 month after treatment.
Two types of time-signal intensity curves post-cryoablation were found: a straight line representing no definite enhancement from 1-day to 1-month,
and an inflow curve representing mild delayed...
Conclusion
MRI findings of lung tumors postcryoablation are characteristic: the volume was the largest at the 1day postcryoabltion and continuously decreased.
The signal intensity on T1WI and T2WI increased heterogeneously at 1-day,
1-week and 1-month and gradually decreased to homogeneous muscle-like level at 3-,
6-and 12-month Absence of a complete hypo-intense rim at 1-week and cavitations at 1-month postcryoablation were suggestive of tumor progression One week to 3-month postcryoablation was an important time period to observe significant change of the ablated zone MRI is valuable in...
Personal information
Jing Li,
PhD.
Department of Radiology,
the Affiliated Cancer Hospital of Zhengzhou University,Henan Cancer Hospital.
Zhengzhou,
China.
Jinrong Qu,
PhD.
Department of Radiology,
the Affiliated Cancer Hospital of Zhengzhou University,Henan Cancer Hospital.
Zhengzhou,
China.
Xiang Geng,
MD.
Department of Interventional treatment,
the Affiliated Cancer Hospital of Zhengzhou University,Henan Cancer Hospital.
Zhengzhou,
China.
Lin Zheng,
MD.
Department of Interventional treatment,
the Affiliated Cancer Hospital of Zhengzhou University,Henan Cancer Hospital.
Zhengzhou,
China.
PhD.
Department of Statistics,
the Affiliated Cancer Hospital of Zhengzhou University,Henan Cancer Hospital.
Zhengzhou,
China....
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