To illustrate the versatile presentation of extranodal lymphoma, from asymptomatic to emergency cases. To point out the imagistic features of extranodal lymphoma on cross- sectional imaging techniques along with the main differential diagnosis. To discuss the role of different imaging techniques in the diagnosis and follow-up of extranodal lymphoma.

Extranodal lymphoma refers to non-Hodgkin or Hodgkin lymphoma involving organs other than lymph nodes, thymus, pharyngeal lymphatic ring, tonsils and spleen. Every organ can be affected by lymphoma. The diagnosis of extranodal lymphoma is crucial as the treatment is mainly based on chemotherapy and radiotherapy, meaning non-surgical. The radiologist should keep in mind that lymphoma is a great disease imitator and be familiar with the imaging characteristics of lymphoma for an accurate diagnosis and an appropriate disease management. In general, lymphamatous involvement of solid organs...

This review illustrates typical and atypical cases of primary or secondary extranodal lymphoma using imaging techniques such as CT, IRM with emphasis on imagistic key features of this disease. This paper does not aim to be an exhaustive presentation of extranodal lymhoma. This review mainly focuses on tricky cases of extranodal lymphoma. Brain and spine Cerebral lymphoma (Fig.2, Fig.3) Primary cerebral lymphoma represents 1-2% of all non-Hodgkin lymphomas and about 2-6% of all brain tumors [2]. Secondary cerebral lymphoma is a central nervous system spread...

Cross-sectional imaging techniques are an essential key step in the diagnosis and management of extranodal lymphoma. The imaging aspect of extranodal lymphoma is often misleading. Therefore, it is crucial to correlate the clinical findings of the patient with the imagistic features of the lesion at ultrasound, CT and IRM in order to make an accurate diagnosis.

Domenico Albano, Giovanni Bosio, Raffaele Giubbini, Francesco Bertagna, 18F-FDG PET/CT and extragastric MALT lymphoma: role of Ki-67 score and plasmacytic differentiation, Leuk Lymphoma. 2017 Mar 7:1-7, [PubMed] Mansour A, Qandeel M, Abdel-Razeq H, Abu Ali HA. MR imaging features of intracranial primary CNS lymphoma in immune competent patients. Cancer Imaging. 2014;14(1):22. doi:10.1186/1470-7330-14-22, [PubMed] Cugati G, Singh M, Pande A, et al. Primary spinal epidural lymphomas. Journal of Craniovertebral Junction and Spine. 2011;2(1):3-11. doi:10.4103/0974-8237.85307. Prokop, Galanski, Schaefer- Prokop, Van der Molen, Spiral and Multislice Computed Tomography...