Lung transplantation (LT) constitutes a therapeutic option that has been escalating, since it constitutes a potentially life-saving procedure. Approximately 3,500 people worldwide receive a transplant every year [3, 11]. Our institution is the fourth largest hospital in Spain by number of performed lung transplantations [1]. Although the number of lung recipients in Spain -and worldwide- continues to increase, death rates following lung transplantation are higher than expected. National 5-year and 10-year survival rates of lung transplant recipients are, respectively, 41.3% and 33.8% [1]. Neurological complications...

Study design and patients A retrospective cohort study of all lung transplant recipients (263 patients: 157 men, 106 women) at a single institution, from January 2010 to January 2017.Data collection occurred between March 2017 and May 2017. All transplant recipients were carefully follow-up at this institution, setting up regular visits with the lung-transplant team.We subsequently reviewed the existing medical records and diagnostic imaging of all patients who underwent lung transplantation between the period specified. The collected demographic features included sex, age, unilateral or bilateral transplantation...

1. Patient demographics (Table1) The three most common indications for lung transplantation in our cohort were chronic obstructive pulmonary disease (34.6%), interstitial lung disease (31.6%) and alpha-1 antitrypsin deficiency (7.2%). Although cystic fibrosis was also a common indication in the younger patients. The most frequent entity of the interstitial lung disease group was the usual interstitial pneumonia. 2. Total of neurological events and brain imaging studies(Figure1) In the 7-year study period, 87 patients had neurological manifestations (33.1 % of the 263 total lung transplants performed)...

We found an elevated rate of neuroimaging findings in patients following LT with 37.3% of positive studies. In our cohort, the frequency of clinical neurological events was 33.1%, lower than those reported in the available studies [2-4 and 9]. One reason for this difference is probably related to the surveillance period. The data collection was made in 2017, so patients who underwent LT from 2014 to 2016 were not followed for a long time (available LT series had a surveillance period of 10 years). Encephalopathy,...

Contact details: Dr. Elena Marín Díez Resident in training.Department of Radiology, Hospital Universitario Marqués de Valdecilla. Av Valdecilla, 25,39008Santander, Spain. Email:[email protected] Dr.Enrique Marco De Lucas Neuroradiology Section. Department of Radiology, Hospital Universitario Marqués de Valdecilla. Av Valdecilla, 25, 39008Santander, Spain. Email: [email protected]

Registro español de trasplante pulmonar.http://www.ont.es/infesp/Registros/MEMORIA%20ANUAL%20RETP%202001-2015.pdf 96 Normal 0 21 false false false ES-TRAD X-NONE X-NONE Mateen FJ, Dierkhising RA, Rabinstein AA, van de Beek D, Wijdicks EFM. Neurological Complications Following Adult Lung Transplantation. Am J Transplant 2010; 10: 908-914.2. Gamez J,Salvado M,Martinez-de La Ossa A,Deu M,Romero L,Roman A,Sacanell J,Laborda C,Rochera I,Nadal M,Carmona F,Santamarina E,Raguer N,Canela M,Solé J.Influence of early neurological complications on clinical outcome following lung transplant. PloS One 2017 Mar 16;12(3). van de Beek D, KremersW, Daly RC et al. Effect of neurologic complications...