Aims and objectives
Despite lung cancer preventive strategies,
lung cancer remains the third highest cause of cancers worldwide [1] with a rising incidence of the disease still being reported [2].
In addition,
lung cancer is the commonest cause of cancer related deaths [3] accounting for around 1.7 million deaths globally each year.
This high mortality rate is at least in part due to the fact that lung cancer is often diagnosed at an advanced stage of disease.
The results of the National Lung Screening Trial (NLST) showed that...
Methods and materials
Patient population: A total of 349 chest CT examinations from 324 unique subjects were retrospectively selected from the NHS Lothian database.
Eligibility of CT scans for each group was determined using information from the radiology reports with cross referencing to the electronic health records as appropriate.
Subjects for the first two groups were selected to mimic a lung cancer screening population.
Inclusion criteria were subjects between 50-74 years of age,
current smokers or those with a smoking history and/or reported to have radiological evidence of...
Results
A total of 337 CT scans from 314 subjects (173 women,
164 men) with a total of 470 pulmonary nodules (largest axial diameter between ≥3mm and ≤30mm) were included in this study.
The mean age of all the subjects was 63 ± 7 years (range 32-88 years).
Details regarding the number of CT scans and nodules per group are described in table 1.
The mean largest axial diameter of all nodules in groups 1 to 5 was 7.68 ± 3.50 mm (range: 3.42 - 28.45...
Conclusion
The mean growth percentage of lung nodule pairs was similar between readers and by stand-alone CAD.
These results show that the tool has the potential to assist radiologists at pulmonary nodule management,
although visual verification of the segmentation is still advised at present.
Personal information
Address for correspondence:
Professor John T Murchison,
Consultant Radiologist,
Royal Infirmary of Edinburgh,
Little France Crescent,
Edinburgh,
UK.
Email:
[email protected]
Declaration of interest:
This study was funded by NHS England via the SBRI Phase 1 grant for earlier detection and treatment of cancer.
Aidence BV received the grant from SBRI and commissioned the University of Edinburgh and Royal Infirmary of Edinburgh to perform the study.
Prof.
J.T.
Murchison,
Dr.
G.
Ritchie and Prof J.R.
van Beek received a consulting fee for reading and annotating the...
References
1.
International Agency for Research on Cancer (IARC).
GLOBOCAN 2018.
2.
Jemal A,
Bray F,
Center MM,
Ferlay J,
Ward E and Forman D (2011) Global cancer statistics.
CA Cancer J Clin 61:69–90
3.
International Agency for Research on Cancer (IARC).
GLOBOCAN Cancer Fact Sheets: Lung Cancer.
International Agency for Research on Cancer (IARC); 2017,
http://gco.iarc.fr/today/data/factsheets/cancers/15-Lung-fact-sheet.pdf.
Accessed 2018.
4.
Centers for Medicare & Medicaid Services (CMS).(2015) Decision memo for screening for lung cancer with low dose computed tomography (LDCT) (CAG-00439N).
CMS website.
www.cms.gov/medicare-coverage-database/details/nca-decision-memo.aspx? NCAId=274.
Accessed...