Relationship between indexed epicardial fat volume and coronary calcium score assessed by cardiac multi-detector CT

Congress:

ESCR 2015

Poster Number:

P-0001

Type:

Scientific Poster

Keywords:

Cardiac, CT, Computer Applications-3D, Calcifications / Calculi

Authors:

D. K. Kang, S. You, S. Y. Park, Y. Baek; Suwon/KR

DOI:

DOI-Link:

https://dx.doi.org/

Fig. 1: 62-year-old female patient with low pretest probability. Agatston calcium score...

Fig. 2: 50-year-old male patient with low pretest probability. Epicardial fat was...

Fig. 3: 43-year-old male patient with intermediate pretest probability underwent...

Fig. 4: Both the baseline (A, C) and follow-up (B, D) EFVi showed positive association...

Purpose

Epicardial fat, which directly surrounds major epicardial coronary arteries, is known to be a rich source of free fatty acids and numbers of bioactive adipocytokines that plays important role in the development of atherosclerosis. Multi-detector computed tomography (MDCT) allows simultaneous assessment of coronary artery calcium, coronary artery stenosis, coronary plaque characteristics, and also epicardial fat volume (EFV), without increased radiation exposure nor additional cost. Although several studies using MDCT have shown a relationship between EFV and coronary artery calcium, it is unknown whether elevated EFV...

Methods and Materials

We retrospectively reviewed clinical and imaging data of 87 patients with coronary artery calcification identified during either baseline or follow-up cardiac MDCT examinations. Clinical cardiovascular risk factors were extracted by medical record review at the times of cardiac MDCT examinations. The 10-year CHD risk based on the Framingham risk score was calculated for each patient. Image acquisition was performed using a Brilliance 64-slice CT scanner (Philips Medical Systems, Eindhoven, The Netherlands) or a dual source 128-slice CT (Somatom Definition FLASH; Siemens Healthcare, Forchheim, Germany). 64-Slice...

Results

Patient characteristics in baseline are listed in Table 1. Table 1. Baseline clinical characteristics of the subjects (n = 87) Characteristics Values (%) Age, yrs 54.8 ± 7.9 Male/Female 69/18 Agatston calcium score, n (%) Zero 31 (35.6) 1-10 17 (19.5) 10-100 25 (28.7) 100-400 14 (16.1) Symptom, n (%) Atypical chest pain 17 (19.5) Non-anginal pain 14 (16.1) Asymptomatic 56 (64.4) Pretest probability, n (%) Intermediates 30 (34.5) Low 55 (63.2) Very low 2 (2.3) The mean interval between baseline and follow-up CT was...

Conclusion

There was no significant association between EFVi andcoronary calcium score. Changes in the coronary calcium score are not accompanied by changes in EFVi. Baseline EFVi does not predict rapid progression of calcium score.

References

1. Gorter PM, de Vos AM, van der Graaf Y, et al. Relation of epicardial and pericoronary fat to coronary atherosclerosis and coronary artery calcium in patients undergoing coronary angiography. Am J Cardiol 2008;102:380-385. 2. Bettencourt N, Toschke AM, Leite D, Rocha J, Carvalho M, Sampaio F, Xará S, Leite-Moreira A, Nagel E, Gama V. Epicardial adipose tissue is an independent predictor of coronary atherosclerotic burden. Int J Cardiol. 2012; 158:26-32. 3. Djaberi R, Schuijf JD, van Werkhoven JM, Nucifora G, Jukema JW, Bax JJ....