Purpose
To evaluate the diagnostic advantages of intravenous USPIO administration on T-staging of uterine carcinoma .
Methods and Materials
Seventeen female patients referred for gynecological carcinomas, 11 with corpus uterine cancer and six with cervical carcinoma underwent MR scan of the pelvis on a 1,5 T magnet. GRE T2*W sequences (TR/TE/FA/matrix/acq. time: 1800msec/15mesc/30/230x512/13,51min) were acquired on multiple planes before and 24 hours after iv administration of 2,6 mg/kg of body weight of Sinerem (Guerbet, Paris, France). Image analysis were performed by consensus by two radiologists and it included qualitative and quantitative analysis of signal intensity (SI) of both normal myometrium and neoplastic lesions before...
Results
Qualitative analysis showed a significant decrease of SI of normal myometrium after Sinerem administration leading to a better lesion conspicuity. Quantitative analysis showed a statistically significant difference between SI of myometrium on plain and Sinerem-enhanced MR images assessed by means of t-test. C/N between lesion and normal myometrium significantly increased following Sinerem administration. In 13 patients Sinerem-enhanced images provided additional information leading to more accurate T staging.
Conclusion
Intravenous injection of Sinerem provides a significant decrease of SI of normal myometrium with higher C/N between neoplastic lesion and normal myometrium increasing the conspicuity of neoplastic lesions.
References
1 Quido G. de Lussanet, Walter H. Backes, Arjan W. Griffioen, Jos M. A. van Engelshoven, and Regina G. H. Beets-Tan Gadopentetate Dimeglumine versus Ultrasmall Superparamagnetic Iron Oxide for Dynamic Contrast-enhanced MR Imaging of Tumor Angiogenesis in Human Colon Carcinoma in Mice Radiology 2003; 229: 429-438. 2 Achim H. Kaim, Gernot Jundt, Thorsten Wischer, Terence O'Reilly, Johannes Frhlich, Gustav K. von Schulthess, and Peter R. AllegriniFunctional-Morphologic MR Imaging with Ultrasmall Superparamagnetic Particles of Iron Oxide in Acute and Chronic Soft-Tissue Infection: Study in Rats Radiology...
Personal Information
This work comes from the radiology departmentof:University of Rome "La Sapienza" Policlinico Umberto I Viale Regina Elena 324 00161 Rome Italy A warm acknowledgment to Dr. Crhistine Weber (Guerbet Protocol Manager).email adress of the first author:
[email protected]
