To measure the difference in liver perfusion parameters using perfusion CT (CT-P) between colorectal carcinoma patients with and without livermetastases, and of various histopathological factors.

Patient population This study was approved by the ethics committee and all patients were required to provide written informed consent before study participation. Inclusion and exclusion criteria were as follows: -Patients had histopathologically proved colorectal cancer, either with surgical or endoscopic specimens. -Patients underwent surgery and were able to determine the pathological stage according to the international TNM classification. -Patients with liver perfusion diseases such as cirrhosis were excluded. -Patients with metastases to organs other than the liver, such as peritoneal dissemination, were also excluded...

CT-P parameters in various histopathological background In all cases, the mean total hepatic BF was 172 ml/min/100g. HAF was 23.5%. No significant correlation was found between BF and the tumor location, macroscopic appearance, size, or histopathological differentiation (Table 1). BF was significantly higher in T3/4 compared to T0/1/2, N1/2 to N0. (Table 2). Comparison of CT-P parameters between livers with and without hepatic metastases BF in cases with overt hepatic metastasis had a tendency to increase compared to cases without metastases (202 vs. 161, P=0.0747)....

The BF values of the hepatic parenchyma reflect the changes in hepatic perfusion due to appearance of metastastic lesions. Perfusion CT may be a method to catch the smallest changes in aortic and portal venous flow to detect the presence of micrometastasis before visualized on any other imaging modality. Limitations *The study sample size of the study, especially the colorectal cancer cases with hepatic metastases, was small, and the statistic differences would not be as accurate as a larger study group. *There was a selection...