ECR 2009 / C-303
Comparison of Intravenous (IV) Isosmolar Contrast (IOCM) vs. Intraarterial (IA) IOCM or Low Osmolar Contrast Media (LOCM): A Prospective Multicenter Trial.
Authors:
R. P. Karlsberg, S. V. Dohad, V. Multicenter Group; Beverly Hills, CA/US
DOI:
10.1594/ecr2009/C-303
Results
- A total of 265 patients underwent CTA with IV iodixanol and had complete SCr measurements.
- A total of 253 of these patients underwent IA DSA with either iodixanol or LOCM administration (3 had both) and had complete SCr measurements. Of these, 148 (58.5%) received iodixanol and 105 (41.5%) received LOCM (iopamidol, 92; ioversol, 8; iohexol, 3; iopromide 2).
- Four of the 148 patients who received iodixanol and 2 of the 105 patients who received LOCM and had complete SCr measurements in the DSA phase did not have complete SCr measurements in the CTA phase.
- Demographic characteristics were comparable for the CTA and IA DSA phases (Table 1).
Table 1. Demographic Characteristics |
Variable | | CTA (N = 265) | IA DSA (N = 253) |
Gender | Female | 96 (36.2%) | 93 (36.8%) |
| Male | 169 (63.8%) | 160 (63.2%) |
| | | |
Race | Asian | 2 (0.8%) | 2 (0.8%) |
| Black | 43 (16.2%) | 40 (15.8%) |
| Caucasian | 204 (77.0%) | 197 (77.9%) |
| Other | 16 (6.0%) | 14 (5.5%) |
| | | |
Age (years) | Mean (SD) | 64.7 (10.9) | 64.4 (10.8) |
| Min, Max | 39, 87 | 39, 87 |
- The patient population had relatively normal renal function, as evidenced by mean (SD) SCr of 93.3 (52.8) µmol/L at the baseline observation prior to CTA.
- Incidence of CIN following IV CTA and IA DSA: 7.5% (20/265) of patients developed CIN following IV iodixanol for CTA and 8.7% (22/253) of patients had CIN following IA iodixanol or LOCM for IA DSA. The difference in incidence was not statistically significant (Figure 2).
Fig.
- Among the 144 patients who received iodixanol and had complete SCr measurements in both phases, CIN developed in 9 patients (6.3%) following IV administration for CTA compared with 8 patients (5.6%) following IA administration for DSA. The difference in incidence was not statistically significant (Figure 3).
Fig.