Keywords:
Breast, Oncology, Computer applications, Nuclear medicine conventional, Mammography, SPECT, Technology assessment, Diagnostic procedure, Cost-effectiveness, Tissue characterisation, Neoplasia, Calcifications / Calculi
Authors:
D. J. Wagenaar1, J. W. Hugg1, R. A. Moats2, S. Chowdhury1, B. E. Patt1; 1Northridge, CA/US, 2Los Angeles, CA/US
DOI:
10.1594/ecr2011/C-1898
Conclusion
MBI Example: 7 mm Lesion
An ongoing screening study at Mayo Clinic with MBI in a cohort of patients with radiographically dense breast has reported promising results of a factor of three improvement in detection sensitivity over mammography in this population [Rh 10]. In Sidebar Figure 1 (Figure 7) we can see an example,
courtesy of Dr.
Michael O’Connor of the Mayo Clinic,
of a 7 mm tubulolobular carcinoma confirmed on biopsy that was called negative on the mammogram. This example demonstrates the potential of MBI to be an effective alternative to mammography in these cases.
Takeaway Message:
Molecular Breast Imaging the LumaGEM can be done with sufficiently low wholebody radiation dose to be a viable screening tool for women with dense breast tissue.
Acknowledgments
Funding from the National Cancer Institute,
grants CA128407 and CA143716,
and the Mayo Foundation is gratefully acknowledged. Also acknowledged are helpful scientific contributions from Drs.
Dirk Meier, Gunnar Maehlum, Joshua Li,
Kevin Parnham,
Carrie Hruska,
and Deborah Rhodes.