Keywords:
Urinary Tract / Bladder, MR, Diagnostic procedure, Contrast agent-intravenous
Authors:
S. Donaldson1, B. Carrington1, R. Cowan1, J. Lyons1, D. Buckley2, S. Bonington1; 1Manchester/UK, 2Leeds/UK
DOI:
10.1594/ecr2011/C-2308
Results
Example images
Fig.
1 shows example images obtained from one patient pre- and post-neo-adjuvant chemotherapy demonstrating the VOIs defined.
Fig.
2 shows the resulting signal-intensity time curves obtained from the rectum VOIs.
The curve obtained before chemotherapy shows a slow increase in signal-intensity while the curve obtained after chemotherapy shows high rapid increase.
This is confirmed by a large increase in perfusion after treatment (pre-treatment Fp = 6.7 ml/100ml/min,
post-treatment Fp = 20.5 ml/100ml/min).
This patient reported significant treatment effects following chemotherapy.
Changes in perfusion before and after treatment
Median perfusion values measured before and after neo-adjuvant chemotherapy are reported in Table 1.
TABLE 1: MEDIAN PERFUSION MEASURED BEFORE AND AFTER TREATMENT
|
Fp (ml/100ml/min)
Median (interquartile range)
|
|
Pre-chemotherapy |
Post-chemotherapy |
Normal bladder wall |
15.5 (3.0 – 20.8) |
18.1 (5.8 – 23.8) |
Rectum |
25.5 (6.5 – 36.4) |
23.4 (5.9 – 22.1) |
Post-chemotherapy perfusion and changes in perfusion
Table 2 shows changes in perfusion values measured pre- and post-chemotherapy separated into those patients who reported no to mild adverse effects and those who reported significant adverse effects.
Large increases in normal tissue perfusion estimates following treatment were found in patients who reported significant adverse effects compared to those who reported no to mild adverse effects. This only reached statistical significance in VOIs defined in the rectum.
TABLE 2: MEAN CHANGES IN PERFUSION MEASURED PRE- AND POST-NEO-ADJUVANT CHEMOTHERAPY
Early reported adverse effects |
|
Mean change in Fp measured pre- and post-chemotherapy |
n |
Normal bladder tissue |
Rectum |
None to mild |
9 |
227% |
-40% |
Significant |
3 |
915% |
716% |
P-value |
- |
0.254 |
0.034* |