Left upper quadrant pathology is relatively less common compared to conditions presenting elsewhere in the abdomen. As a consequence, this region can be a blind spot to radiologists with potential for pathology to be missed. However, pathology here can range from benign diseases to life-threatening conditions, which if overlooked can have a significant impact on patient morbidity and mortality. Making a radiological diagnosis is especially important if the clinical presentation is non-specific, if the findings are incidental or where disease in this region causes referred pain elsewhere.