Keywords:
Musculoskeletal joint, Musculoskeletal soft tissue, MR, Contrast agent-intravenous, Molecular imaging, Tissue characterisation
Authors:
J. van Tiel, M. Reijman, P. K. Bos, J. Verhaar, G. P. Krestin, S. Bierma - Zeinstra, H. Weinans, G. Kotek, E. Oei; Rotterdam/NL
DOI:
10.1594/ecr2013/B-0485
Results
dGEMRIC:
-dGEMRIC median T1 values and hence sGAG content of the cartilage did not improve significantly at 14 weeks follow-up (Figure 4)
-In addition,
the differences in T1 values did not reach an earlier established threshold for improvement in cartilage quality if measmured with dGEMRIC (Van Tiel,
et al.
Eur Radiol.
2013 Feb;23(2):496-504.) (Figure 5)
-The differences in T1 values for each individual participant (data not shown) only reached this threshold in a single ROI at a different location in the knee joint in only 7 participants.
The other ROIs in these participants did not reach the 95 ms threshold.
In the remaining 13 participants,
the threshold for T1 improvement was not reached in any of the analyzed cartilage ROIs
KOOS and Pain Score:
- The KOOS subscales ‘pain’,
‘ADL’,
and ‘sports’ improved significantly 14 weeks after HA injections in the knee (Figure 6)
-The other KOOS subscales ‘symptoms’ and ‘QoL’ showed a positive trend,
but were not significantly different 14 weeks after viscosupplementation (Figure 6)
-The median Pain Score improved significantly 14 weeks after HA injections (Figure 6)