Keywords:
Musculoskeletal joint, Musculoskeletal soft tissue, MR, Contrast agent-intravenous, Molecular imaging, Tissue characterisation
Authors:
J. van Tiel, M. Reijman, P. K. Bos, J. Verhaar, G. P. Krestin, S. Bierma - Zeinstra, H. Weinans, G. Kotek, E. Oei; Rotterdam/NL
DOI:
10.1594/ecr2013/B-0485
Purpose
Viscosupplementation and osteoarthritis:
-Viscosupplementation with hyaluronic acid injections (HA) symptomatic treatment early stage knee osteoarthritis (OA)
-Significant good clinical results vs placebo 5 - 14 weeks after treatment (Bellamy 2006)
-Possibility of disease modifying effects of viscosupplementation
-Positive effect HA on sulphated glycosaminoglycans (sGAG) content of articular cartilage (Goldberg 2005,
Moreland 2003)
dGEMRIC:
-Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC)
-Most sensitive indirect measure cartilage sGAG content (Bashir 1997,
1999)
-Inverse relation sGAG and i.v.
gadolinium
-High T1 represents high sGAG content (Figure 1)
-Highly reproducible in early stage OA patients (Van Tiel,
et al.
Eur Radiol.
2013 Feb;23(2):496-504)
Hypothesis:
“Improvement in clinical symptoms after HA injections will be corroborated by an improvement in sGAG content in the articular cartilage”
Study purpose:
“To assess whether improvement in sGAG content can be detected by dGEMRIC 14 weeks after viscosupplementation in patients with early-stage knee OA”