Keywords:
Pathology, Neoplasia, Cancer, Screening, Imaging sequences, Computer Applications-Detection, diagnosis, MR-Functional imaging, MR-Diffusion/Perfusion, MR, Oncology, Computer applications, Breast
Authors:
D. Tzias1, E. O'flynn2, S. allen1, R. Wilson3; 1london/UK, 2Sutton , Surrey/UK, 3Sutton/UK
DOI:
10.1594/ecr2013/C-0987
Methods and Materials
This study was approved by the local research ethics committee.
57 patients with biopsy proven invasive cancer (23 ILC,
median age 54 years (range 30-72 years); 34 IDC,
median age 49 years (range 31-77 years)) underwent breast DCE-MRI with DWI during 2011 on either a 1.5T Siemens Avanto MR scanner (Siemens Medical Systems,
Erlangen,
Germany) (n=42) or a 1.5T Philips Intera scanner (Philips Healthcare,
Netherlands) (n=15).
Both scanners used a 4 channel breast coil and single shot echoplanar diffusion-weighted sequence employing inversion recovery for fat suppression with 4 b values (0,
350,
700,
1150) and (0,
200,
450,
900) respectively.
A region of interest (ROI) was drawn around the tumour lesion with the largest diameter on a high b value image and then copied and aligned onto the ADC map.
The mean (ADCmean),
minimum (ADCmin) and maximum (ADCmax) values were recorded for each patient.
An independent samples t-test was used to determine any difference in the measured parameters between ILC and IDC.
A typical example of an invasive lobular cancer on mammography,
DCE-MRI and DWI is illustrated in figures 1-4.