This poster is published under an
open license. Please read the
disclaimer for further details.
Keywords:
Interventional non-vascular, Liver, Oncology, CT, Ablation procedures, Cancer, Metastases, Outcomes
Authors:
S. A. Forbes, C. J. Zagorski, P. E. Jennings, R. Soomal, S. L. Smith; Ipswich/UK
DOI:
10.1594/ecr2014/C-1151
Methods and materials
51 tumours in 31 patients treated with radiofrequency ablation (RFA) between 2009 and 2013 during 44 separate procedures were analysed using a prospective database.
All ablation procedures were performed under deep conscious sedation with local anaesthetic infiltrated to the hepatic capsule under US guidance..
Ablation was completed using either the Boston Scientific LeVeen needle (Natuck,
MA,
USA) or the Covidien Cool-tip system (Mansfield,
MA,
USA),
using a single,
double or triple needle arrangement.
An ablation zone extending at least 5mm beyond the margin of the lesion as assessed on an immediate post treatment contrast enhanced CT was considered satisfactory.
If ablation was felt to be unsatisfactory or incomplete,
the needle was repositioned and the lesion retreated.
Patients stayed in hospital one night post ablation.
Follow up whole body CT imaging was performed at 1 month and then at 3 month intervals until three years,
then 6 monthly to 5 years.
All CT was performed using a GE Lightspeed 64-slice CT (GE systems,
Milwaukee,
USA) with dynamic IV contrast enhancement (100mls iodinated contrast (300mg/ml) delivered via a peripheral or central IV line at 3-5ml/sec).
For each patient we recorded the histologically confirmed nature of the primary tumour,
site and number of metastases,
presence of metastases at other sites and if they had received pre-RFA chemotherapy or subsequent liver resection surgery (Table 1).
On a lesion-by-lesion basis the following data was recorded: site and size of the lesion,
technical parameters of the ablation,
length of local tumour progression free period,
significant complications and overall survival.
Survival was calculated from time of first tumour ablation.
Survival data was analysed using Kaplan-Meier survival curves and log rank used for comparison.
A p value < 0.05 was considered statistically significant.
SPSS software version 22.0.0 was used throughout the analysis.