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Keywords:
Neuroradiology brain, MR-Diffusion/Perfusion, Diagnostic procedure, Endocrine disorders
Authors:
J. Bladowska, A. Zimny, P. Szewczyk, P. Tabakow, M. Czyz, M. Kozba-Gosztyla, B. Czapiga, M. Sąsiadek; Wroclaw/PL
DOI:
10.1594/ecr2014/C-1536
Aims and objectives
Sellar/parasellar tumors constitute 10 to 15% of all primary intracranial neoplasms and are the most common causes of pituitary dysfunction and field of view disturbance [1].
Therefore,
early correct diagnosis and therapy of patients with sellar/parasellar tumors are of high importance in clinical practice.
The most common pituitary tumors are adenomas,
which on MR can present various enhancement patterns and other imaging features.
Therefore pituitary adenomas may be mimicked by other tumors located in the sellar region,
such as meningiomas,
craniopharyngiomas,
Rathke cleft cysts,
metastases,
gliomas,
abscesses,
as well as uncommon types of sellar/parasellar tumors like hemangioblastoma.
The plain MR appearance of different sellar/parasellar lesions may be very similar (Fig.1,
Fig.2),
which often leads to misdiagnosis [1].
Since many intracranial tumors are indistinguishable using plain MRI,
the advanced MR techniques,
such as diffusion weighted imaging (DWI),
perfusion weighted imaging (PWI) and magnetic resonance spectroscopy (MRS) can be applied to obtain more information useful in the differential diagnosis.
Nevertheless,
these techniques are rarely used in diagnosis of sellar/parasellar tumors.
There are only a few reports concerning the contribution of DWI and MRS in sellar/parasellar tumors imaging,
and most of them have been performed in small groups of subjects,
and their results are often contradictory [2,3].
The aim of this study is to establish the imaging patterns,
which are typical for different sellar/parasellar tumors,
using the advanced MR techniques.
Therefore this paper will be the first study concerning the contribution of both DWI and PWI in diagnostic imaging of pituitary and parasellar tumors.
The results of this research will provide the noninvasive in vivo imaging biomarkers,
which enable the differential diagnosis of sellar and parasellar tumors.